Dan Connolly is one of four key contributors the New England Patriots will be without Sunday in East Rutherford.

The starting left guard, who left Week 15 with a neck injury, has been ruled inactive for the Week 16 game against the New York Jets. Connolly was limited in practice this week with ankle and knee issues and was listed as questionable on Friday’s injury report.

New England will also be without top power back LeGarrette Blount, wide receiver Julian Edelman and cornerback Kyle Arrington, who were downgraded from questionable to out Saturday evening.

For Blount, it is a shoulder injury that will leave him sidelined. For Edelman, who who was also limited this week, it is a thigh injury and a concussion that left him in Foxborough. And for Arrington, who left last Sunday’s game against the Miami Dolphins in the second quarter, it is a hamstring.

Joining them, the Patriots have also announced that running back James White, guard Jordan Devey and cornerback Alfonzo Dennard are inactive. Through 14 games, the three have been scratched a combined 31 times.

But New England will have rookie jumbo tight end Cameron Fleming back for the first time since the fourth-round pick sustained an ankle injury last month, as the team will go with Fleming, Marcus Cannon and Josh Kline to round out the offensive line.

The Patriots will also go with four tight ends, as tackle-turned-tight end Steve Maneri is active after re-signing with the team this week. And the kicking game will go with linebacker Darius Fleming and core special-teamer Chris White, who is active after missing the last three games with an ankle injury.

As for the Jets, quarterback Matt Simms, wideout Walter Powell, offensive linemen Wesley Johnson and Dakota Dozier, defensive lineman T.J. Barnes, and defensive backs Jaiquawn Jarrett and Rontez Miles are inactive for the 1 p.m. kickoff.